Plasma & Cryo

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When cellular components are removed from anti-coagulated blood, what remains is plasma. Not only is plasma the liquid conduit for carrying cells and oxygen to every other cell in the body, it is rich in nutrients and proteins necessary to those cells.

BCA centers provide more than 2 million Liters of plasma a year for:

Direct patient transfusion (this accounts for roughly half the plasma collected in the U.S.)
Further manufacture (also referred to as ‘plasma for fractionation’) into albumin, IvIG, and other critical medicines developed and distributed to patients around the world.
Non-injectible plasma for production of reagents and other diagnostic uses by life science companies.

If you are interested in discussing your Plasma needs with BCA, please contact Jennifer Ficenec

The following Blood Products are routinely manufactured to meet the specifications outlined below. Modifications in production, volume, storage, and age can be made to produce the ideal product for further manufacture or research and development:

Fresh Frozen Plasma (FFP)

Separated from RBCs in a Whole Blood collection
Frozen within 8 hours
Volume: 200 – 250ml (dependent on donor’s hematocrit)
Contains plasma proteins and coagulation factors
Stored: < -18°C
Shelf-life: 365 days

Apheresis Plasma (FFP)

Collected from a single donor connected to apheresis equipment
Anticoagulant: ACD-
Frozen within 8 hours
Volume: 200 – 600ml
Contains plasma proteins and coagulation factors
Stored: < -18°C
Shelf-life: 365 days

Plasma frozen within 24 hours (FP24)

Separated from RBCs in a Whole Blood collection
Frozen within 24 hours
Volume: 200 – 250ml (dependent on donor’s hematocrit)
Contains plasma proteins and coagulation factors
Stored: < -18°C
Shelf-life: 365 days

Cryo-Reduced Plasma

Plasma refrozen after removal of cryoprecipitate
Deficient in fribrinogen, Factor VIII, Factor XIII, vWF, cryoglobulin, and fibronectin
Stored: < -18°C
Shelf-life: 365 days

Recovered Plasma

Plasma produced in excess of transfusion needs and used for further manufacture into critical medicines like albumin
Separated from RBCs in a Whole Blood collection
Frozen at varying timeframes (e.g., 24 hours, 72 hours, 120 hours)
Volume: 220 – 330ml (dependent on donor’s hematocrit)
Contains plasma proteins and coagulation factors
Stored: < -20°C

Source Plasma

Collected from a single donor with the intention of pooling and fractionating into critical medicines like immune globulin (IgIV)
Plasma collected by apheresis as frequently as every 2 days, provided donor is deemed physically fit
Anticoagulant: ACD or Na Citrate
Frozen within 24 hours (or other according to manufacturer specifications)
Volume: 400 – 800ml
Contains plasma proteins and coagulation factors
Stored: < -20°C

Infrequent Source Plasma

Collected from a single donor with the intention of pooling and fractionating into critical medicines like immune globulin (IgIV)
Plasma only collected by apheresis with a minimum of 28 days between donations
Anticoagulant: ACD or Na Citrate
Frozen within 24 hours (or other according to manufacturer specifications)
Volume: 400 – 800ml
Contains plasma proteins and coagulation factors
Stored: < -20°C

Cryoprecipitate

FFP thawed in refrigerated conditions precipitates out concentrated coagulation factors like fibrinogen, Factor VIII, Factor XIII, vWF and fibronectin
Precipitate is refrozen within 1 hour
Also called Cryo AHF (Cryoprecipitated Antihemophilic Factor)
Volume: 5 – 20 ml
Contains minimum of 80 IU Factor VIII and 150 mg of fibrinogen
Stored: < -18°C
Shelf-life: 365 days

Pooled Cryo

Pooling the precipitates prior to refreezing facilitates transfusion practices
Pooled and refrozen within 1 hour
Number in pool and volumes vary
Stored: < -18°C
Shelf-life: 365 days
Plasma

For more information about BCA’s capabilities please contact Jennifer Ficenec.

Plasma & Cryo

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